To actually manage clients via NoTouch Center, you need to connect them to your NoTouch Center. No worries, this is simple and can be done in a fully automated way! Before you start however, please make sure your URL Prefix value is set up correctly - please see here: URL Prefix
Communication is done via HTTPS or HTTP. Thus, it all boils down to making NoTouch Center's service URL available to the clients. This can happen in multiple ways:
The mere connecting of client and NoTouch Center does not have an effect on clients' configuration. There is no need to worry that this will change the client's behaviour. Directly after connecting clients to NoTouch Center, it will place the client among the "Unassigned" clients, which means no configuration is done. However, adding clients to a group changes the situation: If you decide to add a client to a group, the client will immediateyl inherit the group configuration and all configuration settings done on the client will be overwritten.
Thus, only clients explicitly (by human action or Autoassign) placed into a group will be configured. Clients configured by NoTouch Center are configured only by NoTouch Center and any local administrator changes are overwritten. However, clients are never placed incidentally into a group: you decide if and how you want to do this: manually or automatically, but it is always your decision.
That said, the tcmgr and workgroup deployment methods together with Autoassign allow for a fully automated rollout without even seeing the First Time Wizard.